X-Irradiation at 0.5 Gy after the forced swim test reduces forced swimming-induced immobility in mice
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Antisense to the glucocorticoid receptor in hippocampal dentate gyrus reduces immobility in forced swim test.
Immobility time of rats in the forced swim test was reduced after bilateral infusion of an 18-mer antisense phosphorothioate oligodeoxynucleotide targeted to the glucocorticoid receptor mRNA into the dentate gyrus of the hippocampus. Vehicle-, sense- and scrambled sequence-treated animals spent significantly more time immobile than antisense-treated animals during the initial test. Immunolabeli...
متن کاملPapaver Rhoeas L. Hydroalcoholic Extract Exacerbates Forced Swimming Test-Induced Depression in Mice
Introduction: Depression is one of the most frequent psychiatric disorders in the world with occurs with higher incidence in women. In the present study, the effect of water-alcoholic extract of Papaver rhoeas L. on forced swimming test (FST) in Swiss-Webster mice were examined. Methods: We used Swiss-Webster mice (20-25 g) to execute FST on them. The plant extract (1, 10, 30, a...
متن کاملAn anti-immobility effect of spermine in the forced swim test in mice.
BACKGROUND Spermine is one of the naturally occurring ligands that influence the function of the N-methyl-D-aspartate receptor. Similar to other endogenous polyamines present in micromolar concentration in the brain, it may play a role in the modulation of depression. Thus, the present study investigated the suggested antidepressant effect of spermine. METHODS The mouse forced swim test (FST)...
متن کاملLearned Immobility Is Also Involved in the Forced Swimming Test in Mice
monly used for the assessment of the antidepressant-like properties of drugs (Cesana, Ciprandi and Borsini, 1995; Cohen, Perrault and Sanger, 1997; Hemby et al., 1997). In the original Porsolt test (Porsolt, Le Pichon and Jalfre, 1977b), rats are immersed during a fifteen minute pre-test in a cylindrical tank with water. Twenty four hours later, the rats are replaced in the cylinder for five mi...
متن کاملThe 5-HT2 receptor antagonist reduces immobility of mice treated with the atypical antidepressant mianserin in the forced swimming test.
Effects of co-administration with the 5-HT(2) receptor antagonist LY 53857 and the antidepressant mianserin on immobility time in the forced swimming test were investigated in mice. Mianserin did not affect the immobility time at ranges from 1-10 mg/kg, although it elicited anti-immobility effects at 20 mg/kg. Co-administration of the 5-HT(2) receptor antagonist LY 53857 and a subactive dose of...
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ژورنال
عنوان ژورنال: Journal of Radiation Research
سال: 2020
ISSN: 0449-3060,1349-9157
DOI: 10.1093/jrr/rraa022